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November 26, 2022

Post-Infection Immunity Protective Against Delta, CDC Reports, but Vaccines Still Offer Best Defense

Previous infection with the coronavirus appeared to provide stronger protection against the delta variant than did vaccination in a large sample of patients, the Centers for Disease Control and Prevention reported Wednesday.

But in the long term, vaccination still offers the best defense against the virus, the researchers said.

The data was gathered before the widespread rollout of booster shots and the emergence of the omicron variant, so the findings may not be relevant to the current surge, the agency cautioned.

“These findings cannot be generalized to the current omicron wave,” Benjamin Silk, a public health researcher at the CDC, told reporters Wednesday. “It’d be like comparing apples and oranges.”

By the end of November, 1 in 6 U.S. deaths from COVID-19 were occurring in New York and California. Scientists analyzed testing, surveillance and immunization data from the two states to gauge the level of protection offered by vaccines and previous infection.

Unvaccinated people were at the highest risk of infection or severe illness with COVID-19 throughout the study period, the scientists found. But the relative protection afforded by vaccination or prior infection changed with the arrival of the delta variant.

During the week beginning May 30, 2021, vaccinated people who had not experienced COVID-19 had the lowest risk of coronavirus infection and hospitalization, followed by unvaccinated people who had been previously diagnosed with COVID-19.

By the week beginning Oct. 3, however, vaccinated people with a prior diagnosis fared best against the delta variant. Unvaccinated people with a history of COVID-19 also had lower rates of infection and hospitalization than those protected by vaccines alone.

The data is consistent with trends observed in international studies, the researchers said.

Waning of vaccine-derived immunity may explain why vaccinated people were less protected from infection with the delta variant than those who had a prior diagnosis, the researchers said.

A recent study of employees at the Cleveland Clinic suggested that while vaccination does not add much benefit to a prior bout for the first many months, it may offer better protection against symptomatic illness over the long term than does immunity from a previous infection.

“The totality of the evidence suggests really that both vaccination and having survived COVID each provide protection against infection and hospitalization,” said Eli Rosenberg, deputy director for science at the New York State Department of Health.

But having COVID-19 carries significant risk, so “becoming vaccinated and staying up to date with boosters really is the only safe choice,” he said.

This article originally appeared in The New York Times.

Copyright 2022 The New York Times Company

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